Welcome to the MBMN Laboratory at Georgia Tech!
Nanomedicine is the medical application of nanotechnology for treatment and prevention of major diseases including cancer and cardiovascular diseases. Despite the progress and potential of nanomedicines, many cannot reach clinical trials due to critical challenges including poor reproducibility in high volume production and poor predictive validity of in vitro models. To overcome these challenges, we combine advanced micro and nanofabrication, synthetic biomaterials, and high-precision control systems to develop new microfluidic systems for microfluidic assembly, characterization, evaluation, and manufacturing of multicomponent nanomedicines.
We currently focus on two research areas: (i) microfluidic nanomedicine evaluation and screening using microengineered physiological systems called organs-on-chips and (ii) microfluidic assembly and manufacturing of multicomponent and multifunctional nanomedicines for drug delivery applications. We combine these approaches to accelerate the drug discovery and nanomedicine development, and the clinical translation. In close collaboration with other labs at Emory School of Medicine, we currently apply our innovative technologies for the treatment of atherosclerosis, Alzheimer's disease, and brain cancer.
Our fundamental research goal is to understand (1) how cells coordinate responses to a combination of signaling cues in multicellular environments; (2) how bio/nanomaterials assemble and break in dynamically controlled fluid flow; and (3) how biological systems interact with nanomaterials. To answer the questions, we use experimental and computational approaches to build biomimetic systems that integrate bioengineering and nanotechnology in multiscale biosystems.
Our laboratory provides collaborative environments for our lab members from diverse disciplines to learn each other and do interdisciplinary research. We believe that our lab members will be successful in their career with uniqueness and diversity, both of which are preferred or even required nowadays in an industry as well as in academia. Our lab also has diverse collaborative opportunities with other research laboratories in areas of mechanical/electrical/biomedical/chemical engineering and biology/chemistry/materials sciences.
Select Journal Articles
Sei YJ, Ahn J, Kim T, Shin EJ, Santiago-Lopez AJ, Jang SS, Jeon NL, Jang Y, and Kim Y, Detecting the functional complexities between high-density lipoprotein mimetics (2018) Biomaterials 170: 58-69 (Link). Selected as Leading Opinion.
Sei YJ, Ahn SI, Virtue T, Kim T, and Kim Y, Detection of frequency-dependent endothelial response to oscillatory shear stress using a microfluidic transcellular monitor (2017) Scientific Reports 7: 10019 (Link).
Toth MJ, Kim T, and Kim Y, Robust manufacturing of lipid-polymer nanoparticles through feedback control of parallelized swirling microvortices (2017) Lab on a Chip 17: 2805-2813 (Link).
Kim Y*, Lobatto ME*, Kawahara T, Lee Chung B, Mieszawska AJ, Sanchez-Gaytan BL, Fay F, Senders M, Calcagno C, Becraft J, Saung MT, Gordon RE, Ma M, Farokhzad OC, Fayad ZA, Mulder WJM, and Langer R, Probing nanoparticle translocation across the permeable endothelium in experimental atherosclerosis (2014) Proceedings of the National Academy of Sciences (PNAS) 111 (3): 1078-1083 (Link).
Kim Y, Hazar M, Vijayraghavan D, Song J, Jackson TR, Joshi SD, Messner WC, Davidson LA, and LeDuc PR, Mechanochemical actuators of embryonic epithelial contractility (2014) Proceedings of the National Academy of Sciences (PNAS) 111 (40): 14366-14371 (Link).
Kim Y*, Fay F*, Cormode DP, Sanchez-Gaytan BL, Tang J, Hennessy E, Ma M, Moore KJ, Farokhzad OC, Fisher EA, Mulder WJM, Langer R, and Fayad ZA, Single step reconstitution of multifunctional high-density lipoprotein-derived nanomaterials using microfluidics (2013) ACS Nano 7 (11): 9975-9983 (Link).
Kim Y, Lee Chung B, Ma M, Mulder WJM, Fayad ZA, Farokhzad OC, and Langer R, Mass production and size control of lipid-polymer hybrid nanoparticles through controlled microvortices (2012) Nano Letters 12 (7): 3587–3591 (Link).
Kim Y*, Joshi SD*, Messner WC, LeDuc PR, and Davidson LA, Detection of dynamic spatiotemporal response to periodic chemical stimulation in a Xenopus embryonic tissue (2011) PLoS ONE 6(1): e14624 (Link).
Kim Y, Pekkan K, Messner WC, and LeDuc PR, Three-dimensional chemical profile manipulation using two-dimensional autonomous microfluidic control (2010) Journal of the American Chemical Society (JACS) 132(4): 1339-1347 (Link).
2018-20 NIH NIA R21AG056781, PI (MPI: Rangaraju)
2017-22 NIH Director's New Innovator Award, DP2HL142050, PI
2017-22 NSF CAREER Award, CMMI 1653006, Nanomanufacturing, PI
2015-19 AHA National Scientist Development Grant 15SDG25080314, PI
2016-17 Regenerative Engineering and Medicine, PI (Co-PI: Yoon)
2015-17 Coins for Alzheimer's Research Trust (CART), PI (Co-PI: Tansey)
2015-17 NIH NINDS R21NS091682, PI (Co-I: MacDonald)
2014-15 Center for Pediatric Nanomedicine, CHOA, PI (Co-PI: Lam)
2014-15 Regenerative Engineering and Medicine, PI (Co-PI: Tansey)
2014-15 NIH NHLBI PEN, Co-I (PI: Bao)