Aging muscles exhibit significant deficits in repair capacity, leading to the slow and incomplete recovery process. To maintain skeletal muscle homeostasis and repair damaged muscle, a population of dedicated MuSC, or satellite cell, activate, express myogenic transcription factors, migrate, proliferate, and fuse with existing myofibers or form de novo myofibers to complete regeneration. Skeletal muscle microenvironment is composed of myofibers, extracellular matrix, and cellular components including MuSCs, FAPs, MNs, and ECs in the microvascular network. A growing body of recent data highlights that the intricate biophysical and biochemical interactions between MuSCs and their microenvironment dictate cell-fate decision and are vital for proper regenerative function.
We develop a novel muscle-on-a-chip (MOC) platform that mimics the physiologically relevant microenvironment of skeletal muscle.
We are in collaboration with Prof. Young Jang at Georgia Tech to study the systemic effects of circulating soluble factors in parabiosis.